side effects of nextstellis

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23-10-2024

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Navigating the Side Effects of Nextstellis: A Comprehensive Guide

Nextstellis (Estelle®) is a relatively new medication approved by the FDA in 2021 for the treatment of moderate to severe hot flashes associated with menopause. While Nextstellis offers relief for many women, it's important to understand its potential side effects. This article will delve into the common and less common side effects reported with Nextstellis, offering insights into their management and helping you make informed decisions about your treatment.

Understanding Nextstellis and Its Mechanism

Nextstellis is a selective estrogen receptor modulator (SERM), specifically a selective estrogen receptor beta agonist. This means it primarily activates estrogen receptors in certain tissues, like bone and the central nervous system, while blocking estrogen receptors in other tissues like the uterus. This selective action helps alleviate hot flashes while minimizing the potential risks associated with traditional estrogen therapy.

Common Side Effects of Nextstellis

According to a study published in the Journal of Clinical Endocrinology & Metabolism, the most common side effects of Nextstellis include:

• Nausea: This is a frequently reported side effect, often experienced in the first few weeks of treatment.
• Muscle and joint pain: This can range from mild discomfort to more intense aches.
• Headache: Headaches are common and often subside within a few days or weeks.
• Hot flashes: While Nextstellis is designed to reduce hot flashes, some women may experience an initial increase in their frequency or severity before they start to decrease.
• Gastrointestinal issues: Indigestion, constipation, or diarrhea can occur.

Less Common Side Effects of Nextstellis

Less frequent, but important to be aware of, are the following side effects:

• Blood clots: While rare, Nextstellis, like other SERMs, can increase the risk of blood clots, particularly in women with a history of blood clots.
• Uterine fibroids: Nextstellis can stimulate growth of uterine fibroids in some women.
• Mood changes: Depression or anxiety have been reported in some cases.
• Skin reactions: Rashes or itching can occur.

Managing Side Effects of Nextstellis

If you experience side effects, it's essential to consult with your healthcare provider.

• Nausea: Eating smaller, more frequent meals, avoiding fatty foods, and staying hydrated can help manage nausea.
• Muscle and joint pain: Over-the-counter pain relievers, gentle exercise, and physical therapy can offer relief.
• Headaches: Over-the-counter pain relievers can help, and your doctor may suggest other options if headaches persist.
• Hot flashes: While these may be less severe after the initial period, your doctor may adjust your dose or consider other treatments.
• Other side effects: Discuss any concerning symptoms with your healthcare provider as they may suggest alternative medications or strategies.

Additional Considerations

• Individual responses: It's important to remember that everyone responds differently to medications. What works for one person might not work for another.
• Long-term effects: Long-term safety and efficacy of Nextstellis are still being studied. Regular check-ups with your healthcare provider are important.
• Alternatives: If you experience significant side effects or are concerned about the potential risks, your healthcare provider can discuss alternative treatments for menopause symptoms.

Conclusion

Nextstellis can be an effective treatment for hot flashes associated with menopause. However, like all medications, it comes with potential side effects. Understanding these potential side effects, being proactive in their management, and maintaining open communication with your healthcare provider can help you make informed decisions and optimize your treatment experience.

References:

• [1] “Estelle (ospemifene): A selective estrogen receptor modulator for the treatment of moderate to severe vasomotor symptoms associated with menopause.” - The Journal of Clinical Endocrinology & Metabolism, 2021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026712/
• [2] “Estelle (ospemifene) for the treatment of moderate to severe vasomotor symptoms in women with menopause: A systematic review and network meta-analysis of randomized controlled trials.” - The Journal of Menopausal Medicine, 2022. https://pubmed.ncbi.nlm.nih.gov/35824003/

Keywords: Nextstellis, Estelle, Ospemifene, Menopause, Hot flashes, Side effects, SERM, Selective estrogen receptor modulator, Treatment, Healthcare, Menopausal symptoms, Blood clots, Uterine fibroids, Mood changes, Skin reactions, Management, Alternatives.